Detalhe da pesquisa
1.
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.
Cell
; 167(7): 1719-1733.e12, 2016 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27984723
2.
Repression of the Antioxidant NRF2 Pathway in Premature Aging.
Cell
; 165(6): 1361-1374, 2016 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27259148
3.
Hypoxia prevents premature ageing in mice.
Nat Rev Mol Cell Biol
; 24(8): 522, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37291386
4.
Ten principles of heterochromatin formation and function.
Nat Rev Mol Cell Biol
; 19(4): 229-244, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29235574
5.
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.
Nat Rev Mol Cell Biol
; 18(10): 595-609, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28792007
6.
H2A.Z is involved in premature aging and DSB repair initiation in muscle fibers.
Nucleic Acids Res
; 52(6): 3031-3049, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38281187
7.
Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model.
Proc Natl Acad Sci U S A
; 120(47): e2309200120, 2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37967221
8.
Impaired DNA demethylation of C/EBP sites causes premature aging.
Genes Dev
; 32(11-12): 742-762, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29884649
9.
Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity.
Hum Mol Genet
; 32(19): 2901-2912, 2023 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37440454
10.
Excessive apoptosis of Rip1-deficient T cells leads to premature aging.
EMBO Rep
; 24(12): e57925, 2023 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37965894
11.
The nuclear lamins: flexibility in function.
Nat Rev Mol Cell Biol
; 14(1): 13-24, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23212477
12.
Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging.
J Immunol
; 210(11): 1641-1652, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37058108
13.
Mitochondrial Electron Transport Chain Complex II Dysfunction Causes Premature Aging of Hematopoietic Stem Cells.
Stem Cells
; 41(1): 39-49, 2023 01 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36219686
14.
Nuclear proteostasis imbalance in laminopathy-associated premature aging diseases.
FASEB J
; 37(8): e23116, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37498235
15.
Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet.
Immunity
; 42(1): 133-44, 2015 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25601202
16.
WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer.
Bioessays
; 44(8): e2200057, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35751457
17.
The BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor-Guillermo progeria syndrome cells.
Nucleic Acids Res
; 50(16): 9260-9278, 2022 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36039758
18.
Genomic instability in the naturally and prematurely aged myocardium.
Proc Natl Acad Sci U S A
; 118(36)2021 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34465617
19.
Potential of Curcumin in the Management of Skin Diseases.
Int J Mol Sci
; 25(7)2024 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38612433
20.
The WMI Rat of Premature Cognitive Aging Presents Intrinsic Vulnerability to Oxidative Stress in Primary Neurons and Astrocytes Compared to Its Nearly Isogenic WLI Control.
Int J Mol Sci
; 25(3)2024 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38338968